How genomic information is accessed in clinical practice: an electronic survey of UK general practitioners.

Genomic technologies are having an increasing impact across medicine, including primary care. To enable their wider adoption and realize their potential, education of primary health-care practitioners will be required. To enable the development of such resources, understanding where GPs currently access genomic information is needed. One-hundred fifty-nine UK GPs completed the survey in response to an open invitation, between September 2017 and September 2018. Questions were in response to 4 clinical genomic scenarios, with further questions exploring resources used for rare disease patients, direct-to-consumer genetic testing and collecting a family history. Respondents were most commonly GP principals (independent GPs who own their clinic) (64.8%), aged 35-49 years (54%), worked as a GP for more than 15 years (44%) and practiced within suburban locations (typically wealthier) (50.3%). The most popular 'just in time' education source for all clinical genomic scenarios were online primary care focussed resources with general Internet search engines also popular. For genomic continuous medical education, over 70% of respondents preferred online learning. Considering specific scenarios, local guidelines were a popular resource for the familial breast cancer scenario. A large proportion (41%) had not heard of Genomics England's 100,000 genome project. Few respondents (4%) would access rare disease specific Internet resources (Orphanet, OMIM). Twenty-five percent of respondents were unsure how to respond to a direct-to-consumer commercial genetic test query, with 41% forwarding such queries to local genetic services. GPs require concise, relevant, primary care focussed resources in trusted and familiar online repositories of information. Inadequate genetic education of GPs could increase burden on local genetic services

People v. Davis: California\u27s Murder Statute and the Requirement of Viability for Fetal Murder

In People v. Davis, the California Supreme Court held that the viability of a fetus is not required for a murder conviction under California Penal Code section 187(a). The Davis court ruled that the third-party killing of a fetus with malice aforethought is murder under California\u27s murder statute so long as the state can show that the fetus has progressed beyond the embryonic stage of seven to eight weeks. This decision overturned eighteen years of California appellate court holdings

S-Matrix on the Moyal Plane: Locality versus Lorentz Invariance

Twisted quantum field theories on the Groenewold-Moyal plane are known to be non-local. Despite this non-locality, it is possible to define a generalized notion of causality. We show that interacting quantum field theories that involve only couplings between matter fields, or between matter fields and minimally coupled U(1) gauge fields are causal in this sense. On the other hand, interactions between matter fields and non-abelian gauge fields violate this generalized causality. We derive the modified Feynman rules emergent from these features. They imply that interactions of matter with non-abelian gauge fields are not Lorentz- and CPT-invariant.Comment: 15 pages, LaTeX, 1 figur

AMCTD: Adaptive Mobility of Courier nodes in Threshold-optimized DBR Protocol for Underwater Wireless Sensor Networks

In dense underwater sensor networks (UWSN), the major confronts are high error probability, incessant variation in topology of sensor nodes, and much energy consumption for data transmission. However, there are some remarkable applications of UWSN such as management of seabed and oil reservoirs, exploration of deep sea situation and prevention of aqueous disasters. In order to accomplish these applications, ignorance of the limitations of acoustic communications such as high delay and low bandwidth is not feasible. In this paper, we propose Adaptive mobility of Courier nodes in Threshold-optimized Depth-based routing (AMCTD), exploring the proficient amendments in depth threshold and implementing the optimal weight function to achieve longer network lifetime. We segregate our scheme in 3 major phases of weight updating, depth threshold variation and adaptive mobility of courier nodes. During data forwarding, we provide the framework for alterations in threshold to cope with the sparse condition of network. We ultimately perform detailed simulations to scrutinize the performance of our proposed scheme and its comparison with other two notable routing protocols in term of network lifetime and other essential parameters. The simulations results verify that our scheme performs better than the other techniques and near to optimal in the field of UWSN.Comment: 8th International Conference on Broadband and Wireless Computing, Communication and Applications (BWCCA'13), Compiegne, Franc

Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic)

Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation. It presents: a brief view of the uncertainty classification: Aleatory uncertainty comes from the inherent uncertain nature and phenomena, and epistemic uncertainty comes from the lack of knowledge, a formulation of the tolerance analysis problem based on this classification, its development: Aleatory uncertainty is modeled by probability distributions while epistemic uncertainty is modeled by intervals; Monte Carlo simulation is employed for probabilistic analysis while nonlinear optimization is used for interval analysis.“AHTOLA” project (ANR-11- MONU-013